GREEN BAY, Wis. -- Bryan Bulaga will miss time because of the ankle injury he suffered in practice on Wednesday, but the Green Bay Packers still are trying to determine how much time.

Coach Mike McCarthy ruled Bulaga out for Saturday’s preseason game in Denver, where quarterback Aaron Rodgers and the starting offense are expected to see their most extensive playing before the season opener against Seattle.

Bulaga’s injury could alter McCarthy’s plan for Rodgers, considering the coach never likes to put his quarterback in preseason games without the regular starting offensive line.

“We’ll talk about it,” McCarthy said. “I want to make sure we get all the information."

Bulaga has a history of knee injuries, so when he went down in practice on Wednesday, the worst was feared. He missed all of 2013 with a torn ACL in his left knee and parts of 2014 and 2015 with problems in the same knee. Bulaga is coming off his best season since the first knee injury. He played in all 16 games for the first time since 2010, his rookie year.

The 28-year-old eighth-year pro was hurt Wednesday during a 9-on-7 run game drill. He was down on the field for a minute before he limped off under his own power. He left the field with a member of the Packers’ medical staff and did not return.

“We’re actually still doing some testing, so I do not have a timeline,” McCarthy said Thursday. “But he’s feeling better today than he was yesterday.”

Second-year pro Kyle Murphy, a former sixth-round pick, probably will start in place of Bulaga against the Broncos. He got the nod over fellow second-year pro Jason Spriggs in practice after Bulaga dropped out. Spriggs, a second-round pick, struggled in last week’s preseason game in Washington, where he had a hand in as many as three sacks allowed.

“Really like where they’re at,” McCarthy said. “Looks like they’re taking that step in their second year. They’ve had good camps. I have confidence in both those guys. It’s a very healthy competition.”