Scherff has a sprained right MCL and is expected to miss three to five weeks, a source told ESPN, confirming an NFL Network report.
Players must miss a minimum of three weeks when placed on IR under rules instituted for the 2020 season because of the coronavirus pandemic.
Coach Ron Rivera had said on his Zoom news conference Monday that the team received good news about Scherff, but that he would still miss time.
Wes Schweitzer will replace Scherff, as he did Sunday. Schweitzer has made 36 career starts.
This is the third consecutive year Scherff has landed on injured reserve. He had missed a combined 13 games the past two seasons because of a torn pectoral muscle in 2018 and elbow and shoulder injuries last season. Scherff still was voted to the Pro Bowl last season. He has made three Pro Bowl teams since Washington made him the fifth overall pick in 2015.
Washington must make a decision on Scherff's long-term future after this season. He is playing on the franchise tag in 2020.
Washington promoted Cam Sims from its practice squad Tuesday in a corresponding move. Sims is a third-year receiver who has two career NFL catches. He mostly has been used on special teams.
Washington travels to Cleveland to face the Browns on Sunday.
ESPN's John Keim and The Associated Press contributed to this report.