Moody's pick: Saints 27, Seahawks 24
Walder's pick: Seahawks 19, Saints 16
FPI prediction: NO, 72.6% (by an average of 6.9 points)
Matchup must-reads: The Seahawks have needed every bit of Geno Smith's unlikely success ... Andy Dalton gave Saints' offense a spark, but bigger issues loom after 1-3 start ... ... Saints' Alvin Kamara (rib) expects to play against Seahawks
Titans (2-2) at Commanders (1-3)
1 p.m. ET | CBS
Spread: TEN -1.5 (42.5)
What to watch for: Washington has done a nice job stopping the run the past two weeks against the Eagles and Cowboys, allowing an NFL-best 2.27 yards per carry and tying for second at 67 yards allowed during that stretch. The Commanders have allowed 1.17 yards after contact, also second best the past two weeks. But the Commanders' run defense will be severely tested by Tennessee running back Derrick Henry. He started slow, but has run for 199 yards combined the past two weeks and ranks third in the NFL in yards after first contact at 3.21 in that time. -- John Keim
Bold prediction: Titans quarterback Ryan Tannehill will finish with 300 passing yards in a win over the Commanders. He will find a way to connect with a receiver group that will be missing first-round pick Treylon Burks. Tannehill had only two 300-yard passing games last season and has yet to have one this year. Washington's pass defense is allowing 259.8 yards per game, but 294 yards per game at home. -- Turron Davenport
Stat to know: The Titans have allowed a player to record six or more receptions in each of their four games this season. Commanders WR Curtis Samuel has 26 receptions this season, tied with Travis Kelce and Davante Adams for eighth most in the NFL.
Injuries: Titans | Commanders
What to know for fantasy: Henry didn't catch a single pass in the first two weeks but has eight (for 91 yards) over the past two weeks. See Week 5 rankings.
Betting nugget: Washington has failed to cover in three straight games. Read more.
Moody's pick: Commanders 30, Titans 27
Walder's pick: Commanders 20, Titans 16
FPI prediction: WSH, 60.9% (by an average of 3.1 points)
Matchup must-reads: Titans rookie WR Treylon Burks exits game with leg injury ... Rivera OK with 'frustrations' amid 1-3 start ... Commanders patient with Wentz despite rough stretch ... RB Robinson returns to practice after being shot in robbery attempt
Texans (0-3-1) at Jaguars (2-2)
1 p.m. ET | CBS
Spread: JAX -7.0 (43.5)
What to watch for: Texans running back Dameon Pierce is coming off the first 100-yard game of his career (which included a 75-yard TD run) and ranks 10th in the NFL in rushing. The Jaguars were leading the NFL in rush defense until giving up 210 yards and four rushing touchdowns in a loss at Philadelphia last weekend. Expect the Texans to feed the Jaguars a heavy dose of Pierce, especially with run-game anchor Foley Fatukasi dealing with a quad injury. -- Mike DiRocco
Bold prediction: Texans wideout Brandin Cooks will have his best outing of the season with a 100-yard game. This season, Cooks has zero 100-yard receiving games and has averaged just 53 yards per game. But in Cooks' five career games against the Jaguars, he has averaged 120 yards with five touchdowns. That'll help the Texans continue their eight-game winning streak over the Jaguars. -- DJ Bien-Aime
Stat to know: Trevor Lawrence struggles under pressure, having the largest drop-off of any QB in QBR (-76) compared to when he's not pressured. When pressured, he ranks in the bottom of the league in QBR, completion percentage and yards per attempt.
Injuries: Texans | Jaguars
What to know for fantasy: Pierce has more than 100 scrimmage yards and a rushing score in consecutive games. His six catches last week against the Chargers are 60% of his grabs for the season. See Week 5 rankings.
Betting nugget: The past four times Jacksonville was a favorite, it lost the game outright, with three of those losses coming against Houston. Read more.
Moody's pick: Jaguars 34, Texans 14
Walder's pick: Jaguars 31, Texans 9
FPI prediction: JAX, 71.8% (by an average of 6.6 points)
Matchup must-reads: Texans release starting TE Pharaoh Brown ... After loss, the Jaguars look to rebound against AFC South ... How LSU and the SEC prepared Texans rookie Derek Stingley Jr. for the NFL ... Former Jaguars QB Blake Bortles says he 'quietly' retired
49ers (2-2) at Panthers (1-3)
4:05 p.m. ET | CBS
Spread: SF -6.5 (39)
What to watch for: Things have not being going well for Baker Mayfield. He has had 11 passes batted down at the line of scrimmage, six more than any quarterback in the NFL this season. He has also been sacked 11 times, tied for the eighth most in the NFL. San Francisco's defense had seven sacks and 17 quarterback pressures on Monday night against the Rams. The 49ers are tied for second in the NFL in sacks with 15 -- which is not a good omen for Mayfield. -- David Newton
Bold prediction: San Francisco 49ers defensive end Nick Bosa will have three sacks in his second career game against the Panthers. Bosa dominated Carolina in 2019 with three sacks and an interception. He is leading the NFL in sacks and pressures this year. What's more, it's Mayfield at quarterback for the Panthers this time, the same signal-caller Bosa made a point of terrorizing in 2019 with two sacks, a forced fumble and a fumble recovery. Another big day could be in store for Bosa here, and don't be surprised if he brings back the "flag plant" celebration he used against Mayfield in that previous meeting. -- Nick Wagoner
Stat to know: The 49ers are 0-2 and averaging 10.0 points per game on the road this season -- and 2-0, 25.5 PPG at home. They haven't lost three straight road games since 2018.
Injuries: 49ers | Panthers
What to know for fantasy: Christian McCaffrey has set the bar so high that three straight games with more than 100 scrimmage yards isn't enough to put him in the good graces of fantasy managers. See Week 5 rankings.
Betting nugget: Carolina is 3-15 ATS in its past 18 games. Read more.
Moody's pick: 49ers 27, Panthers 10
Walder's pick: 49ers 23, Panthers 14
FPI prediction: CAR, 56.2% (by an average of 1.8 points)
Matchup must-reads: Jimmie Ward year away from being among rarefied 49ers company ... Mayfield struggles, but Panthers don't have another option ... Nick Bosa says 49ers' defense has personnel to be 'best in the league' ... Mayfield takes blame for offense's struggles amid 1-3 start ... Darnold's return from IR not close, coach Matt Rhule says
Eagles (4-0) at Cardinals (2-2)
4:25 p.m. ET | FOX
Spread: PHI -5.0 (49.5)
What to watch for: The Cardinals will have their work cut out for them passing and defending the ball. Philadelphia is allowing a league-low 4.75 yards per pass, and the Cardinals are ranked 30th in passing yards per play (5.37). Additionally, the Eagles are averaging a league-high 8.79 passing yards per play while the Cardinals are giving up 7.36, which ranks 25th in the league. -- Josh Weinfuss
Bold prediction: Arizona will double its sack total on the season and take Jalen Hurts down four times. The Cards are dead last in the league with four sacks entering Week 5. They're catching the Eagles' normally dominant offense at the right time, with left tackle Jordan Mailata (shoulder) and right guard Isaac Seumalo (ankle) dealing with injuries. Jack Driscoll, who hasn't started a game at left tackle since college, has been getting the work on Hurts' blind side this week. While he acquitted himself generally well in a tough spot when Mailata went down against the Jaguars on Sunday, Arizona should have some opportunities to affect the passer. -- Tim McManus
Stat to know: The Eagles are the only team to win the turnover battle in every game this season. They have an NFL-best plus-eight turnover margin.
Injuries: Eagles | Cardinals
What to know for fantasy: Marquise Brown has scored at least 12.8 fantasy points in every game this season and has at least 11 targets in three straight games. The role is great, but don't forget DeAndre Hopkins' suspension has just two weeks left on it. See Week 5 rankings.
Betting nugget: Arizona is 19-9 ATS in September/October under Kliff Kingsbury (12-3 ATS in October). Read more.
Moody's pick: Eagles 30, Cardinals 17
Walder's pick: Eagles 23, Cardinals 20
FPI prediction: ARI, 56.4% (by an average of 1.8 points)
Matchup must-reads: Miles Sanders' emergence makes the Eagles so much better ... Defense keeps Cardinals afloat while offense figures it out
Cowboys (3-1) at Rams (2-2)
4:25 p.m. ET | FOX
Spread: LAR -5.5 (43)
What to watch for: Matthew Stafford has been sacked 16 times this season, which is tied for the second most in the NFL. Meanwhile, the Cowboys are tied for second in the league with 15 sacks and own the best pass rush win rate in the NFL (56.3%), according to ESPN Metrics powered by NFL Next Gen Stats. So it is possible things don't get better for Stafford this week. -- Sarah Barshop
Bold prediction: CeeDee Lamb will finish with more catches than Cooper Kupp. Through four games, Kupp has been targeted 54 times with 42 catches for 402 yards. Lamb has been targeted 42 times with 23 catches for 288 yards. The Cowboys will be the third pass defense the Rams have faced so far ranked in the top seven, and their varied pass rush will make life difficult for Stafford. With the return of Michael Gallup, Lamb will have chances to get away from Jalen Ramsey to make more plays. -- Todd Archer
Stat to know: The Rams have been outscored 44-3 with an NFL-worst minus-41 point differential in the fourth quarter this season -- they have outscored opponents by 17 in the first three quarters.
Injuries: Cowboys | Rams
What to know for fantasy: Tony Pollard averaged 3.0 catches per game through two weeks, but in the past two weeks, he has a total of 2 receiving yards. See Week 5 rankings.
Betting nugget: Since the start of last season, Dallas is 9-1 ATS on the road and 13-2 ATS in conference games. Read more.
Moody's pick: Cowboys 23, Rams 20
Walder's pick: Rams 27, Cowboys 17
FPI prediction: LA, 65.1% (by an average of 4.7 points)
Matchup must-reads: Jerry Jones: An 'injustice' not to give coach McCarthy credit ... Police report filed in Wagner tackle ... Cowboys D reaching elite levels of legendary Doomsday Defense? ... How drawing plays benefits McVay, others ... Markquese Bell capitalizing on Cowboys opportunity
Bengals (2-2) at Ravens (2-2)
8:20 p.m. ET | NBC
Spread: BAL -3.0 (48)
What to watch for: The Ravens have lost a franchise-worst five straight home games (by a total of 12 points), dating back to last season. This is the second-longest current home losing streak in the NFL behind the Cardinals, who have dropped seven in a row at home. Bengals quarterback Joe Burrow has excelled in his past eight road games, going 6-2 with 18 touchdowns and four interceptions. Thus, breaking the streak won't be easy for the Ravens. -- Jamison Hensley
Bold prediction: Ja'Marr Chase will have more than 125 receiving yards. Baltimore's defense has struggled, and the amount of damage opposing teams have done through the air bodes well for the Bengals and Chase, who has received extra attention from opposing teams this season. -- Ben Baby
Stat to know: Joe Burrow has 12 touchdowns on passes of 20-plus yards downfield since the start of last season. He is tied with Russell Wilson for the most in the NFL in that span.
Injuries: Bengals | Ravens
What to know for fantasy: With two games of seven-plus targets already this season, plus a TD reception in Week 4, Bengals tight end Hayden Hurst has potential. See Week 5 rankings.
Betting nugget: Baltimore is 12-2-2 ATS when the line is between +3 and -3 since 2019 (Lamar Jackson's first full season as starter). Read more.
Moody's pick: Bengals 27, Ravens 24
Walder's pick: Ravens 30, Bengals 26
FPI prediction: CIN, 52.7% (by an average of 0.9 points)
Matchup must-reads: Burrow: Concussions come with the game ... The 61-0 streak is over: Why the Ravens are no longer the NFL's best closers
Raiders (1-3) at Chiefs (3-1)
Monday 8:15 p.m. ET | ESPN
Spread: KC -7.0 (51)
What to watch for: The Raiders might need to score a big number in order to win. Patrick Mahomes has been as good against the Raiders as any opponent, with a 7-1 record, 22 touchdowns and just three interceptions. Last year alone, Mahomes threw seven touchdowns with no interceptions in two games as the Chiefs scored a combined 89 points. -- Adam Teicher
Bold prediction: Raiders cornerback Amik Robertson will have a takeaway against the Chiefs. Listed at 5-foot-8, 187 pounds, he stood tall against Denver last week with a 68-yard scoop-and-score TD and played tough defense against Jerry Jeudy. Meanwhile, Mahomes has thrown two interceptions, and the team has also lost two fumbles through four games. -- Paul Gutierrez
Stat to know: The Chiefs have won six straight home games on Monday Night Football with the last loss coming in 2004 against the Patriots.
Injuries: Raiders | Chiefs
What to know for fantasy: Derek Carr has completed over 70% of his passes in four straight games against the Chiefs and cleared 18 fantasy points in three of those contests. See Week 5 rankings.
Betting nugget: Mahomes is 7-1 outright and 6-2 ATS against Las Vegas. Read more.
Moody's pick: Chiefs 41, Raiders 24
Walder's pick: Raiders 30, Chiefs 27
FPI prediction: KC, 62% (by an average of 3.7 points)
Matchup must-reads: Raiders, Josh McDaniels savor first win vs. division rival, former employer Broncos ... Mahomes' 'Houdini' play leads Chiefs' bounce-back ... Without Tyreek Hill, Chiefs' receiving load shifting to tight ends and backs ... Patrick Mahomes says Andy Reid 'stole the show' in TV ad
Giants (3-1) at Packers (3-1) in London
9:30 a.m. ET | NFL Network
Spread: GB -8.0 (41)
What to watch for: This could be a nightmare matchup for the Packers' defense. It ranks in the bottom third of the NFL in yards allowed per carry (5.0), and the Giants -- with the NFL's leading rusher, Saquon Barkley -- run it at the second-best clip in the league (5.8 yards per carry). It prompted Packers coach Matt LaFleur to say this week that defensive coordinator Joe Barry needs to have his players "play more physical" and "in certain situations you might have to put an extra defender in the box." -- Rob Demovsky
Bold prediction: Aaron Rodgers throws for 300-plus yards and at least three touchdowns. Rodgers hasn't topped 255 yards passing this season, and the Giants have the eighth-ranked pass defense. But New York also hasn't faced a quarterback like Rodgers and has a pedestrian 9.0 sacks and a 29.0% pressure rate, per NFL Next Gen Stats. This could be Rodgers' breakout game. As Giants defensive coordinator Wink Martindale said of the Packers QB, 'It's like owning a python and saying, 'Don't worry about it, he won't bite.'" -- Jordan Raanan
Stat to know: Rodgers is averaging 6.2 air yards per attempt, his fewest through four games since becoming a starter in 2008. His 43.1 QBR this season is also his worst through the first four games in that same time frame.
Injuries: Giants | Packers
What to know for fantasy: Barkley has more than 20 carries or a rushing TD in all four games this season and leads the league in percentage of team offense accounted for (40.4%). See Week 5 rankings.
Betting nugget: Over the past 15 seasons, teams favored by at least seven points in international games are 7-0 ATS (6-0 ATS in London). Read more.
Moody's pick: Packers 31, Giants 14
Walder's pick: Packers 24, Giants 12
FPI prediction: GB, 86.9% (by an average of 13.5 points)
Matchup must-reads: How Saquon Barkley and AJ Dillon became the 'Quad Kings' of the NFL ... Landon Collins, Giants finalizing deal, sources say ... Packers' Aaron Rodgers wanted longer London trip ... Rodgers: 'This way of winning, I don't think, is sustainable'