Lamar Jackson is no stranger to facing the Cincinnati Bengals.
On Thursday, the Baltimore Ravens quarterback appears in his 11th game as a starter against his division rivals -- and the scorecard hasn't been close.
Jackson is 9-1 in starts against Cincinnati, the only blemish being a 41-17 loss in Week 7 of the 2021 season. He needed overtime to defeat the Bengals in Week 6 this year, throwing for 348 yards and four touchdowns in a 41-38 win.
Jackson has thrown for 2,182 yards, 18 touchdowns and four interceptions against Cincinnati. He has also averaged 74.5 rushing yards per game, the most rushing yards by any quarterback vs. a single opponent since 1950 when quarterback starts were first tracked (min. 10 starts).
Jackson isn't the only signal-caller to attain significant success against a single opponent.
Here's a look back at some quarterbacks with regular-season dominance against a single opponent since 2000 (minimum 15 games).
Tom Brady vs. Buffalo Bills
Record: 33-3
Win percentage: .917
Brady haunted Bills fans across 20 seasons, turning a win against them into almost a formality.
His regular-season win percentage of .917 is the second best by any quarterback against a single opponent. Only the Dallas Cowboys' Roger Staubach had a better percentage, going 16-1 (.941) against the New York Giants. Brady's 33 wins are the most by any quarterback against a single opponent in a regular season -- he's also in second with 30 wins against the Jets.
He threw for 9,032 yards plus 72 touchdowns and 25 interceptions. Brady had arguably his best performance against Buffalo in 2007, throwing for 373 yards and five touchdowns in a 56-10 win.
Ben Roethlisberger vs. Cleveland Browns
Record: 25-2-1
Win percentage: .911
Big Ben took care of business against the Pittsburgh Steelers' division rivals.
He started 10-0 against the Browns, with his first loss coming in a low-scoring affair in 2009. Roethlisberger then remained undefeated against Cleveland in the regular season the rest of his career -- though the Steelers lost to the Browns in the 2020 playoffs 48-37.
Dak Prescott vs. New York Giants
Record: 13-2
Win percentage: .867
Prescott dropped his first two games against the Giants but hasn't lost since -- a remarkable streak that continued this season.
Prescott's 13 straight wins against New York are tied for the second-longest winning streak by a quarterback against a single opponent since 1950. Miami's Bob Griese has the longest with 17 wins against the Bills.
His best performance came in 2019 when he threw for 405 yards and four touchdowns in a 35-17 victory.
Joe Flacco vs. Cleveland Browns
Record: 18-3
Win percentage: .857
Before he led them to an improbable run to the 2023 playoffs, Flacco was associated with negative memories for Cleveland fans.
Similar to Roethlisberger, he had a hot start against the Browns, winning his first 11 meetings. Even when he left the AFC North and joined the Jets in 2022, Flacco still haunted Cleveland. He threw for 307 yards and four touchdowns in a win against the Browns in 2022.
Peyton Manning vs. Houston Texans
Record: 17-3
Win percentage: .850
Whether he was with the Indianapolis Colts or Denver Broncos, Manning found success vs. the Texans.
He threw for 5,853 yards plus a strong touchdown-interception ratio of 48 to eight. Manning had two 400-yard passing games, including 433 in 2010 -- the sixth most of his career. After dropping two straight matchups against the Texans across 2010 and 2012, Manning won the last eight meetings.
While playing Houston in 2013, Manning set the single-season record for most touchdowns.
Aaron Rodgers vs. Minnesota Vikings
Record: 17-12-1
Win percentage: .566
The New York Jets quarterback has started 30 games against the Vikings, tied for his most versus any opponent.
Even though his win percentage is just over .500, Rodgers has won 17 of his 30 starts, tied with Brett Favre for the most wins by any quarterback vs. Minnesota. Bart Starr is second at 11.
He has thrown for 7,401 yards, 59 touchdowns and 11 interceptions against the Vikings. In their lone playoff matchup in the 2012 NFC wild-card round, Rodgers threw for 274 passing yards and one touchdown in a 24-10 win.
ESPN Research contributed to this report.