Week 6 of the 2024 college football season is highlighted by a Friday night doubleheader with ranked teams and a slew of conference matchups. Michigan State heads to Eugene to face No. 6 Oregon for the first time in Big Ten play. Oregon will look to keep momentum rolling ahead of a marquee Week 7 matchup with No. 3 Ohio State.
Meanwhile No. 25 UNLV, fresh off its first victory without former QB Matthew Sluka, will face former Buckeye Kyle McCord and Syracuse. The Saturday slate features No. 9 Missouri and No. 25 Texas A&M (Noon p.m. ET on ABC/ESPN+).
Things wrap up with an ACC nightcap as Cam Ward and No. 8 Miami head to Berkley for the first time to face California (10:30 p.m. ET on ESPN).
Here are all the odds and lines for games with Top 25 teams on the Week 6 slate.
All odds are accurate as of timestamp. For the latest odds go to ESPN BET.
Michigan State at No. 6 Oregon (-24)
Friday, 9 p.m. ET, FOX
Records: Michigan State 3-2; Oregon 4-0
Opening Line: Oregon -24.5, O/U 52.5 (-105)
Money line: Michigan State (+1100); Oregon (-2000)
Over/Under: 52.5 (O -105, U 115)
FPI Projection Oregon by 22.7 points, 92% probability to win game
Syracuse at No. 25 UNLV (-5)
Friday, 9 p.m. ET, FS1
Records: Syracuse 3-1; UNLV 4-0
Opening Line: UNLV -4.5, O/U 57.5 (-115)
Money line: Syracuse (+160); UNLV (-190)
Over/Under: 58.5 (O -120, U VEN)
FPI Projection UNLV by 12.5 points, 79% probability to win game
UCLA at No. 7 Penn State (-28)
Saturday, Noon ET, FOX
Records: UCLA 1-3; Penn State 4-0
Opening Line: Penn State -27.5, O/U 45.5 (EVEN)
Money line: UCLA (+2500); Penn State (-7500)
Over/Under: 45.5 (O EVEN, U 120)
FPI Projection Penn State by 27.3 points, 95% probability to win game
No. 9 Missouri (-1) at No. 25 Texas A&M
Saturday, Noon ET, ABC, ESPN+
Records: Missouri 4-0; Texas A&M 4-1
Opening Line: Texas A&M -2, O/U 49.5 (-105)
Money line: Missouri (+EVEN); Texas A&M (-120)
Over/Under: 49.5 (O -110, U 110)
FPI Projection Missouri by 0.7 points, 52% probability to win game
SMU at No. 22 Louisville (-7)
Saturday, Noon ET, ESPN
Records: SMU 4-1; Louisville 3-1
Opening Line: Louisville -7, O/U 58.5 (EVEN)
Money line: SMU (+210); Louisville (-250)
Over/Under: 57.5 (O -110, U -110)
FPI Projection Louisville by 6.6 points, 67% probability to win game
Iowa at No. 3 Ohio State (-20.5)
Saturday, 3:30 p.m. ET, CBS
Records: Iowa 3-1; Ohio State 4-0
Opening Line: Ohio State -23.5, O/U 42.5 (-115)
Money line: Iowa (+800); Ohio State (-1400)
Over/Under: 44.5 (O -110, U -110)
FPI Projection Ohio State by 19.6 points, 90% probability to win game
Auburn at No. 5 Georgia (-23.5)
Saturday, 3:30 p.m. ET, ABC, ESPN+
Records: Auburn 2-3; Georgia 3-1
Opening Line: Georgia -23.5, O/U 49.5 (-105)
Money line: Auburn (+1500); Georgia (-3500)
Over/Under: 52.5 (O -115, U -105)
FPI Projection Georgia by 21.1 points, 91% probability to win game
No. 12 Ole Miss (-9) at South Carolina
Saturday, 3:30 p.m. ET, ESPN
Records: Ole Miss 4-1; South Carolina 3-1
Opening Line: Ole Miss -10, O/U 51.5 (-105)
Money line: Ole Miss (-350); South Carolina (+280)
Over/Under: 51.5 (O -110, U -110)
FPI Projection Ole Miss by 10.3 points, 75% probability to win game
No. 23 Indiana (-13.5) at Northwestern
Saturday, 3:30 p.m. ET, BTN
Records: Indiana 5-0; Northwestern 2-2
Opening Line: Indiana -13, O/U 43.5 (-115)
Money line: Indiana (-600); Northwestern (+450)
Over/Under: 42.5 (O -115, U -105)
FPI Projection Indiana by 15.8 points, 85% probability to win game
No. 1 Alabama (-24) at Vanderbilt
Saturday, 4:15 p.m. ET, SEC Network
Records: Alabama 4-0; Vanderbilt 2-2
Opening Line: Alabama -24.5, O/U 55.5(-110)
Money line: Alabama (-2000); Vanderbilt (+1100)
Over/Under: 55.5 (O EVEN, U -120)
FPI Projection Alabama by 22.3 points, 92% probability to win game
No. 15 Clemson (-15) at Florida State
Saturday, 7 p.m. ET, ESPN
Records: Clemson 3-1; Florida State 1-4
Opening Line: Clemson -15.5, O/U 46.5 (-110)
Money line: Clemson (-800); Florida State (+550)
Over/Under: 46.5 (O -115, U -105)
FPI Projection Clemson by 12.6 points, 80% probability to win game
Utah State at No. 21 Boise State (-26)
Saturday, 7 p.m. ET, FS2
Records: Utah State 1-3; Boise State 3-1
Opening Line: Boise State -28, O/U 65.5 (-110)
Money line: Utah State (+1500); Boise State (-3500)
Over/Under: 65.5 (O -110, U -110)
FPI Projection Boise State by 30.1 points, 97% probability to win game
No. 4 Tennessee (-14) at Arkansas
Saturday, 7:30 p.m. ET, ABC
Records: Tennessee 4-0; Arkansas 3-2
Opening Line: Tennessee -13.5, O/U 60.5(-115)
Money line: Tennessee (-525); Arkansas (+400)
Over/Under: 59.5 (O -115, U -105)
FPI Projection Tennessee by 14 points, 82% probability to win game
No. 10 Michigan at Washington (-2.5)
Saturday, 7:30 p.m. ET, NBC
Records: Michigan 4-1; Washington 3-2
Opening Line: Washington -2.5, O/U 41.5 (EVEN)
Money line: Michigan (+125); Washington (-145)
Over/Under: 40.5 (O -115, U -105)
FPI Projection Washington by 2.9 points, 58% probability to win game
No. 11 USC (-9.5) at Minnesota
Saturday, 7:30 p.m. ET, Big Ten Network
Records: USC 3-1; Minnesota 2-3
Opening Line: USC -9.5, O/U 51.5 (-110)
Money line: USC (-360); Minnesota (+290)
Over/Under: 51.5 (O -110, U -110)
FPI Projection USC by 8.4 points, 71% probability to win game
Baylor at No. 16 Iowa State (-13.5)
Saturday, 7:30 p.m. ET, FOX
Records: Baylor 2-3; Iowa State 4-0
Opening Line: Iowa State -12.5, O/U 46.5 (-105)
Money line: Baylor (+450); Iowa State (-600)
Over/Under: 46.5 (O -110, U -110)
FPI Projection Iowa State by 10.9 points, 77% probability to win game
No. 8 Miami at California (-12.5)
Saturday, 10:30 p.m. ET, ESPN
Records: Miami 5-0; California 3-1
Opening Line: Miami -13.5, O/U 55.5 (-110)
Money line: Miami (-500); California (+380)
Over/Under: 55.5 (O -105, U -115)
FPI Projection Miami by 8.5 points, 72% probability to win game