While some teams have clinched playoff spots and thus have the luxury of resting their starters, others in win-and-in situations are dealing with injuries at key positions.
The Jacksonville Jaguars can take the AFC South if they win on the road against the Tennessee Titans, but they might have to do it without starting quarterback Trevor Lawrence. The Jaguars will wait until game time to see if his sprained right AC joint will allow him to throw well enough to play.
The Tampa Bay Buccaneers can capture the NFC South if they win on the road against the Carolina Panthers, and things look a little better for them with starting quarterback Baker Mayfield. He practiced in full on Friday despite some discomfort with his ribs.
The Atlanta Falcons can displace the Bucs atop the NFC South if Tampa stumbles, but they have their own issues at quarterback. They've had a revolving door at the position this season, and current starter Taylor Heinicke is questionable with an ankle injury. They'll go back to Desmond Ridder if Heinicke can't play.
Here are more injury updates from our NFL Nation reporters as we head into the final weekend of the regular season.
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Trevor Lawrence, QB, Jacksonville Jaguars
Injury: Sprained right AC joint
Coach Doug Pederson said Lawrence could be a game-time decision, depending on how his shoulder feels on Saturday and Sunday after he does more throwing Friday. If it doesn't respond well, the Jaguars will go with C.J. Beathard in a game they must win to claim the AFC South.
-- Michael DiRocco
Baker Mayfield, QB, Tampa Bay Buccaneers
Injury: Ribs
Coach Todd Bowles said Friday that Mayfield will be "full go" against the Carolina Panthers. Mayfield was limited Thursday and was a full participant in Friday's practice. Additional testing revealed no cracks or fractures. Mayfield said his ribs feel "tender" and that it's just a matter of pain tolerance and needing to stay loose throughout the game.
-- Jenna Laine
Taylor Heinicke, QB, Atlanta Falcons
Injury: Left ankle
Heinicke is officially listed as questionable with an ankle injury sustained two weeks ago against Indianapolis. Heinicke told ESPN he'll need to go through warmups Sunday before the game against the New Orleans Saints and see how it feels. If Heinicke can't go, Desmond Ridder probably will get the start for Atlanta in a game the Falcons have to win (and then have Carolina beat Tampa Bay) to make the postseason.
-- Michael Rothstein
Rashee Rice, WR, Kansas City Chiefs
Injury: Hamstring
Rice, the Chiefs' leading wide receiver by a large margin, didn't practice all week and won't play Sunday against the Los Angeles Chargers. The Chiefs also will be without wide receiver Kadarius Toney (hip and ankle) and cornerback L'Jarius Sneed (calf). Toney also missed the past two games.
-- Adam Teicher
Lamar Jackson, QB; Odell Beckham Jr., WR, Baltimore Ravens
Injury: Coaching decision
Jackson will miss his first start of the season because coach John Harbaugh has decided to rest him, Beckham and a handful of other starters. The Ravens have already clinched the AFC's No. 1 seed. Tyler Huntley will start in place of Jackson. Over the previous two seasons, the Ravens were 2-8 in December and January without Jackson, averaging 18.6 points per game.
With WR Zay Flowers (calf) listed as doubtful, the Ravens probably will start Rashod Bateman and Nelson Agholor at wide receiver.
-- Jamison Hensley
Josh Jacobs, RB, Las Vegas Raiders
Injury: Quad
Jacobs has missed three straight games for the first time in his five-year career, and the reigning NFL rushing champion will miss a fourth, it was announced Friday. Jacobs, an All-Pro last season, averaged a career-low 3.5 yards per carry this season. In his absence, second-year running back Zamir White has averaged 4.8 yards per carry in rushing for a combined 285 yards and a TD in those three starts.
-- Paul Gutierrez
Tee Higgins, WR, Cincinnati Bengals
Injury: Hamstring
Higgins didn't practice all week. While the Bengals will evaluate him throughout the weekend, it looks like a long shot for him to play in the finale.
-- Ben Baby
Hunter Henry, TE, New England Patriots
Injury: Knee
Henry injured a knee in the Week 15 loss to the Chiefs and hasn't played since. He was limited all week in practice and was ruled out Friday. The eight-year veteran is scheduled for unrestricted free agency in the offseason after totaling 42 receptions for 419 yards and six touchdowns this season.
-- Mike Reiss
Jonathan Allen, DT, Washington Commanders
Injury: Knee
Allen, who missed the Pro Bowl this season after earning a berth each of the previous two years, was ruled out of Sunday's finale. Allen started the first 16 games and has missed only three games in the past six years. He finishes the year with 5.5 sacks, the most by any current Commander, though end Montez Sweat, traded in October, had 6.5 with Washington.
-- John Keim
Christian Watson, WR, Green Bay Packers
Injury: Hamstring
Watson took Friday off after practicing Wednesday and Thursday -- his first on-field work since the Dec. 3 injury. Both Watson and coach Matt LaFleur said that was by design. "I went kind of hard the first two days," Watson said Friday. "So just to kind of give me the best chance to go on Sunday was to rest a little bit today and make sure that I do everything to take care of my body and put myself in the best position to hopefully play on Sunday."
-- Rob Demovsky
Minkah Fitzpatrick, S, Pittsburgh Steelers
Injury: Knee
For the first time since injuring a knee in the Week 15 loss to the Indianapolis Colts, Fitzpatrick is questionable to play. He has been ruled out the past two weeks but has a real chance to play in a crucial game. Inside linebacker Elandon Roberts is also listed as questionable with a pec injury, but he was emphatic that he will play against the Baltimore Ravens.
-- Brooke Pryor
Darnell Mooney, WR; Jaylon Johnson, CB, Chicago Bears
Injury: Concussion; shoulder
Mooney will miss his second consecutive game with a concussion, which could mean we've seen the last of the receiver in a Bears uniform. The fourth-year wideout is headed toward free agency after a disappointing season marked by career lows in receptions (31), receiving yards (414) and touchdowns (1).
Johnson left the Falcons game after 20 snaps with a shoulder injury and did not practice this week. The cornerback, who is listed as doubtful, said the day after receiving his first Pro Bowl honor that his plan is to try to play against the Green Bay Packers.
-- Courtney Cronin
Keenan Allen, WR, Los Angeles Chargers
Injury: Heel
Allen will miss his fourth straight game with a heel injury that has kept him from adding to an already record-breaking season. Allen finishes the year with a 108 receptions -- a single-season franchise record -- and 1,243 yards.
-- Kris Rhim
Jameson Williams, WR, Detroit Lions
Injury: Ankle
Williams was held out of practice all week and was ruled out for Sunday's regular-season finale against the Minnesota Vikings. He appeared to roll both ankles after catching a 63-yard bomb from QB Jared Goff in the fourth quarter of Detroit's 20-19 loss at Dallas on Dec. 30 and was spotted limping out of the locker room after the game.
-- Eric Woodyard
DeVonta Smith, WR, Philadelphia Eagles
Injury: Ankle
Smith exited Lincoln Financial Field in a walking boot and crutches and has been ruled out. His recovery appears to be going well, however. He has since ditched the walking boot and crutches and was walking in the locker room without a limp throughout the week. Smith and corner Darius Slay (knee) appear on track to return for the playoffs.
-- Tim McManus
Deonte Banks, CB, New York Giants
Injury: Shoulder
The Giants' first-round pick was a limited participant at practice this week after missing the Week 17 loss to the Los Angeles Rams. But he's doubtful for Sunday vs. the Philadelphia Eagles. You're not going to see the rookie in the finale. It just doesn't make sense.
-- Jordan Raanan
Eddy Pineiro, K, Carolina Panthers
Injury: Hamstring
Although Pineiro said he would kick if possible Sunday, he's listed as doubtful, which puts Matthew Wright in the spotlight. Interim coach Chris Tabor wouldn't say what Wright's range is, but Wright has connected from 59 yards, so the Panthers at least have a good option that they didn't last week when Pineiro began feeling discomfort in warmups.
-- David Newton
Alvin Kamara, RB, New Orleans Saints
Injury: Ankle
Kamara sprained an ankle against the Tampa Bay Buccaneers on Sunday and did not practice all week. Saints coach Dennis Allen said Kamara will be a game-time decision against the Atlanta Falcons on Sunday. He is officially listed as questionable.
-- Katherine Terrell