Captain Owen Farrell and hooker Jamie George will miss England's final autumn test against South Africa on Saturday due to injuries sustained in last weekend's 32-15 win over Australia, the Rugby Football Union said on Monday.
Farrell, who missed England's opening autumn series game after a false positive COVID-19 test, suffered an ankle injury that forced him off in the second half, while George hurt his knee and did not take the field after half-time.
Gloucester duo Harry Elrington, an uncapped prop, and hooker Jack Singleton were added to the squad on Monday while prop Joe Marler will join on Friday after completing his 10-day COVID isolation period.
Coach Eddie Jones' side will be looking to complete a flawless autumn series on Sunday after wins against Tonga and Australia.