Washington (1-4) at Giants (0-5)

1 p.m. ET | Fox

Matchup rating: 9.0 | Spread: NYG -3 (43)

What to watch for: We get Washington defensive end Chase Young up against Giants left tackle Andrew Thomas -- the No. 2 overall pick from April matched against the struggling No. 4 overall selection. It's been a rough start for Thomas, as he's ranked 61st out of 68 tackles in pass-block win rate (79.4%), an ESPN metric powered by NFL Next Gen Stats. Young, meanwhile, flashed his form early before missing some time with a groin injury. He returned last weekend and should be close to 100 percent and a handful for Thomas off the edge. -- Jordan Raanan

Bold prediction: Washington defensive end Montez Sweat will take advantage of a weak New York offensive line and beat right tackle Cameron Fleming for a sack/fumble that leads to a deciding touchdown for Washington. Furthermore, Washington will record four sacks to break a three-game skid against the Giants. It ranks fifth in sacks with 15, but eight occurred in the opener. Against this line, Washington's pass rush will get healthy. -- John Keim

Stat to know: The Giants are last in the NFL in rushing, with just 79.0 yards per game. But Washington is second to last at 81.4 rushing yards per game.

Injuries: Washington | Giants

What to know for fantasy: In Weeks 2-4, Giants wide receiver Darius Slayton totaled 134 yards on nine catches. In Week 5, he racked up 129 yards on eight catches against a divisional foe in the Cowboys. In Week 6, he gets another NFC East rival that has been routinely challenged deep down the field by opponents. See Week 6 rankings.

Betting nugget: In the past 35 seasons, when a team with an 0-5 or worse record is favored, the under is 12-6. Read more.

Keim's pick: Washington 21, Giants 20

Raanan's pick: Giants 23, Washington 22

FPI prediction: WSH, 52.7% (by an average of 1 point)

Matchup must-reads: Resetting Washington's QB situation: What's next for Allen, Smith and Haskins ... Giants' Jones continues to be haunted by last-minute failures ... Smith favored to win comeback player award ... Giants lose LB Carter for season with ruptured Achilles