Week 13's biggest matchup is a rematch of last year's NFC Championship Game: The Philadelphia Eagles opened as 1-point favorites over the visiting San Francisco 49ers, but the line has already moved quickly.
In the other 12 games, some big favorites will be looking to shine in the prime-time spotlight, beginning with the Dallas Cowboys hosting the Seattle Seahawks on Thursday night. On Sunday night, the Kansas City Chiefs visit the Green Bay Packers for Patrick Mahomes' first foray at Lambeau Field. The week's finale will see the Cincinnati Bengals limp into a matchup with the Jacksonville Jaguars for "Monday Night Football" on ABC and ESPN.
We've got lines for every matchup, updated throughout the week.
Favorites are selected by ESPN's Football Power Index (FPI). Odds by ESPN BET.
Indianapolis Colts -1 @ Tennessee Titans
Nissan Stadium, Nashville, Tennessee
Sunday 1 p.m. ET
Money Line: Indianapolis Colts (-115) ; Tennessee Titans (-105)
Total: 42.5; Opened: 41.5
FPI favorite: Colts by 2.5 (57.5% to win outright)
Betting Nuggets
Mike Vrabel is 12-6 outright and ATS as a home underdog in his career. That is the best outright winning percentage as a home underdog of any coach in the Super Bowl era (minimum 10 games).
The Colts are 3-0 ATS as favorites this season.
The Titans are 0-5 ATS against teams currently with winning records this season.
The Titans are 4-1 outright and ATS at home this season. The Colts are 4-1 outright and ATS on the road this season.
Los Angeles Chargers -5.5 @ New England Patriots
Gillette Stadium, Foxborough, Massachusetts
Sunday 1 p.m. ET
Money Line: Los Angeles Chargers (-240) ; New England Patriots (+200)
Total: 39.5; Opened: 41.5
FPI favorite: Chargers by 6 (67.5% to win outright)
Betting Nuggets
The Patriots are 1-11 ATS in their last 12 games as underdogs, including 1-6 ATS this season.
Unders are 8-1 in the Chargers' last nine games.
The Chargers are 0-3 ATS in their last three games.
Detroit Lions -4.5 @ New Orleans Saints
Caesars Superdome, New Orleans
Sunday 1 p.m. ET
Money Line: Detroit Lions (-210) ; New Orleans Saints (+175)
Total: 46.5; Opened: 44.5
FPI favorite: Lions by 2.1 (56.4% to win outright)
Betting Nuggets
The Saints are 2-8-1 ATS this season (0-3 ATS in last three games, 1-5 ATS last six games).
The Saints are 0-4 ATS at home this season.
The Lions are 4-1 ATS on the road (3-0 ATS as road favorites).
The Saints have covered four straight games as underdogs.
The Lions have covered five straight games after a loss.
Atlanta Falcons -2 @ New York Jets
MetLife Stadium, East Rutherford, New Jersey
Sunday 1 p.m. ET
Money Line: Atlanta Falcons (-135) ; New York Jets (+115)
Total: 33.5; Opened: 35.5
FPI favorite: Falcons by 2.3 (57% to win outright)
Betting Nuggets
The Falcons are 0-6 ATS in their last six games as favorites (1-6 ATS this season).
The Jets are 0-4 ATS in their last four games. The Falcons are 2-8 ATS in their last ten games.
Unders are 5-1 in the Jets' last six games
Arizona Cardinals @ Pittsburgh Steelers -6.5
Acrisure Stadium, Pittsburgh
Sunday 1 p.m. ET
Money Line: Arizona Cardinals (+230) ; Pittsburgh Steelers (-280)
Total: 41.5; Opened: 39.5
FPI favorite: Steelers by 7.7 (71.8% to win outright)
Betting Nuggets
Kyler Murray is 14-5-1 ATS in his career as a road underdog (11-9 outright).
Kenny Pickett is 15-8 ATS in his career.
Unders are 9-2 in Steelers games this season, the highest under percentage in the league.
The Steelers are 5-0 ATS against teams currently with losing records this season.
Carolina Panthers @ Tampa Bay Buccaneers -3.5
Raymond James Stadium, Tampa, Florida
Sunday 1 p.m. ET
Money Line: Carolina Panthers (+160) ; Tampa Bay Buccaneers (-190)
Total: 36.5; Opened: 38.5
FPI favorite: Buccaneers by 7.5 (71.3% to win outright)
Betting Nuggets
Baker Mayfield is 12-24-1 ATS in his career as a favorite, the second-worst record of any quarterback as a favorite in the Super Bowl era (min. 30 games as favorite).
The Panthers are 2-8-1 ATS this season, all as an underdog. They are 1-5 ATS on the road.
Five straight Panthers games have gone under the total. Four straight Buccaneers home games have gone under the total.
The Buccaneers have won and covered five of the last six meetings.
Miami Dolphins -9 @ Washington Commanders
FedExField, Landover, Maryland
Sunday 1 p.m. ET
Money Line: Miami Dolphins (-450) ; Washington Commanders (+360)
Total: 49.5; Opened: 49.5
FPI favorite: Dolphins by 11.4 (80.4% to win outright)
Betting Nuggets
The Dolphins are 6-1 ATS as favorites this season. They are also 6-1 ATS against teams currently with losing records.
The Commanders are 1-4 ATS at home this season.
The Commanders are 3-0-1 ATS and 2-2 outright as home underdogs of at least 7.5 points under Ron Rivera.
Denver Broncos @ Houston Texans -3
NRG Stadium, Houston
Sunday 4:05 p.m. ET
Money Line: Denver Broncos (+135) ; Houston Texans (-160)
Total: 47.5; Opened: 44.5
FPI favorite: Texans by 1.5 (54.6% to win outright)
Betting Nuggets
Russell Wilson is 20-6 ATS in his career as an underdog of at least 3.5 points (22-7-2 ATS when getting at least three points).
The Texans are 0-7 ATS in their last seven games as favorites, including 0-4 ATS this season.
The Broncos are 4-1 ATS in their last five games. The Texans are 1-5 ATS in their last five games.
Unders are 5-1 in the Broncos' last six games.
Cleveland Browns @ Los Angeles Rams -4
SoFi Stadium, Inglewood, California
Sunday 4:25 p.m. ET
Money Line: Cleveland Browns (+170) ; Los Angeles Rams (-200)
Total: 40.5; Opened: 38.5
FPI favorite: Rams by 3.2 (59.5% to win outright)
Betting Nuggets
The Browns have covered six straight games after a loss and are 8-0-1 ATS in their last nine games after a loss (3-0 ATS this season).
All five Browns road games have gone over the total this season.
The Browns are 3-0 outright and ATS against teams currently with losing records this season. All three games went under the total. The Rams are 0-4 ATS in their last four games against teams with winning records.
The Browns are 12-4-1 ATS in non-conference games under Kevin Stefanski.
San Francisco 49ers -3 @ Philadelphia Eagles
Lincoln Financial Field, Philadelphia
Sunday 4:25 p.m. ET
Money Line: San Francisco 49ers (-155) ; Philadelphia Eagles (+135)
Total: 47.5; Opened: 46.5
FPI favorite: 49ers by 1.9 (55.6% to win outright)
Line Movement Alert: Opened Eagles -1
Betting Nuggets
The Eagles are the second team in the Super Bowl era with a 10-1 or better record to be a regular season home underdog with their primary quarterback.
Brock Purdy is 10-5-1 ATS in his first 16 regular-season starts including 5-0 ATS when laying less than four points.
The Eagles have covered six straight games when the line is between +3 and -3 and are 4-0 ATS in that role in the last two seasons (3-0 ATS this season).
The Eagles have covered three straight games and four of their last five games.
Kansas City Chiefs -6 @ Green Bay Packers
Lambeau Field, Green Bay, Wisconsin
Sunday 8:20 p.m. ET
Money Line: Kansas City Chiefs (-270) ; Green Bay Packers (+220)
Total: 42.5; Opened: 41.5
FPI favorite: Chiefs by 7.6 (71.7% to win outright)
Betting Nuggets
The Packers are 18-8 ATS as underdogs under Matt LaFleur, including 4-1 outright and ATS as home underdogs.
Andy Reid is 0-6 ATS in his last six games against the Packers (including playoffs), and he is 0-3 ATS against them as the Chiefs coach.
The Chiefs are 1-6 ATS in their last seven prime-time games (1-3 ATS this season).
The Packers are 1-4 ATS against teams currently with winning records this season.
Six of the Chiefs' last seven games have gone under the total (last week went over).
Cincinnati Bengals @ Jacksonville Jaguars -9.5
TIAA Bank Field, Jacksonville, Florida
Monday 8:15 p.m. ET
Money Line: Cincinnati Bengals (+380) ; Jacksonville Jaguars (-500)
Total: 39.5; Opened: 41.5
FPI favorite: Jaguars by 5.8 (66.8% to win outright)
Line Movement Alert: Opened Jaguars -7.5
Betting Nuggets
The Jaguars are 8-3 ATS this season and 7-1 ATS in their past eight games.
The Jaguars are 6-1 as a favorite this season.
The Bengals are 15-7 ATS on the road over the last three seasons.
Home favorites of at least seven points are 12-21-1 ATS on Monday Night Football.
Monday Night Football unders are 13-1 this season with 11 straight unders since Week 3.