Cardinals (2-2) at Jets (0-4)
1 p.m. ET | Fox
Matchup rating: 22.4 | Spread: ARI -7 (46.5)
What to watch for: Forget about elite; Jets quarterback Joe Flacco, starting for the injured Sam Darnold, will be hard-pressed to reach "average." He hasn't started a game in nearly a year and has had very little practice time after missing training camp. A rusty, immobile quarterback behind a leaky offensive line is not a good combination. The Jets are 31st in red-zone efficiency, while the Arizona defense is fourth. Do the math. -- Rich Cimini
Bold prediction: The Cardinals will put up 40 on the lowly Jets, who are giving up 32.8 points per game, the third most in the NFL. The Cardinals are averaging 24.5 points per game, but their offense is due for a breakout after struggling over the past two weeks. And what's a better time to do it than against one of the worst teams in football? -- Josh Weinfuss
Stat to know: Arizona receiver DeAndre Hopkins has 39 receptions, which leads the NFL. He needs nine against the Jets to break the record for the most catches through a team's first five games of a season.
What to know for fantasy: Arizona QB Kyler Murray and Buffalo QB Josh Allen are the only two players, regardless of position, with at least 21 fantasy points in all four weeks this season. See Week 5 rankings.
Betting nugget: The Jets are 0-4 ATS this season. They are failing to cover games by 10.5 points per game, the worst cover differential in the NFL this season. Read more.
Weinfuss' pick: Cardinals 42, Jets 28
Cimini's pick: Cardinals 24, Jets 13
FPI prediction: ARI, 57.1% (by an average of 2.5 points)
Matchup must-reads: How Jones' unique body has him nearing 100 sacks ... Can former champ Flacco end Jets' misery? Wrong time, wrong team ... Baker to play after missing one week