Serie A leaders Juventus suffered a shock 2-1 defeat at Napoli on Sunday, with coach Maurizio Sarri returning to his former club for the first time,
Lazio's 11-match winning run in Serie A was ended on Sunday following a 1-1 derby draw with AS Roma that was decided by two goalkeeping errors.
Second-placed Inter Milan were held to a third successive 1-1 draw after Radja Nainggolan, on loan at Cagliari, equalised for the visitors.
Josip Ilicic scored a hat-trick as Atalanta thrashed Torino 7-0 on the road, a game in which the hosts went down to nine men in a forgettable night.
AC Milan forward Ante Rebic scored the winning goal they beat Brescia 1-0, sparing the blushes of Zlatan Ibrahimovic.
The Derby della Capitale is always intense but with Lazio in the title race and Roma battling for fourth, Sunday's derby means even more than usual.
The Egyptian's finish against Manchester United may prove to be one of the defining images of Liverpool's side's utter conviction in their destiny.
Free-scoring Atalanta missed a chance to move back into the top four of Serie A when they suffered a shock 2-1 home defeat on Monday against SPAL.