Week 5 of the 2023 NFL season kicks off on Thursday night as Justin Fields and the Chicago Bears face Sam Howell and the Washington Commanders. The stale for Sunday features 12 games highlighted by a marquee "Sunday Night Football" showdown between the Dallas Cowboys and San Francisco 49ers. Week 5 wraps up with "Monday Night Football" when Jordan Love and the Green Bay Packers visit Allegiant Stadium to take on the Las Vegas Raiders.
Check back here daily for updated lines and information from ESPN Stats & Information.
Lines courtesy of Caesars Sportsbook. Football Power Index (FPI) by ESPN Sports Analytics Group.
Jacksonville Jaguars @ Buffalo Bills -4.5
Tottenham Hotspur Stadium, London
Sunday 9:30 AM ET
Money Line: Jacksonville Jaguars (+192) ; Buffalo Bills (-235)
Total: 48.5; Opened: 46.5
FPI favorite: Bills by 11.2 (79.2% to win outright)
Betting Nuggets
Doug Pederson is 32-23 ATS in his career as an underdog including playoffs. He is 9-6 ATS as an underdog with the Bills.
The Bills have covered three straight games.
The Jaguars are 5-5 ATS all-time in London games.
Overs are 5-1 at Tottenham Hotspur Stadium.
Houston Texans @ Atlanta Falcons -2.5
Mercedes-Benz Stadium, Atlanta
Sunday 1:00 PM ET
Money Line: Houston Texans (+115) ; Atlanta Falcons (-135)
Total: 42; Opened: 41
FPI favorite: Falcons by 1 (52.8% to win outright)
Betting Nuggets
The Falcons are 0-3 ATS in their past three games.
The Texans are 4-1 ATS in their past five road games.
Arthur Smith is 4-6 ATS as a home favorite.
Carolina Panthers @ Detroit Lions -9.5
Ford Field, Detroit
Sunday 1:00 PM ET
Money Line: Carolina Panthers (+345) ; Detroit Lions (-455)
Total: 44; Opened: 43.5
FPI favorite: Lions by 10.3 (77.3% to win outright)
Betting Nuggets
They are 14-5 ATS at home under Dan Campbell, the best ATS record in that span.
Jared Goff is 58-43-2 ATS in his career, including 58-36-2 ATS since his second season (0-7 ATS as rookie).
Frank Reich is 5-2-1 ATS in his career as at least a six-point underdog.
Tennessee Titans -2.5 @ Indianapolis Colts
Lucas Oil Stadium, Indianapolis
Sunday 1:00 PM ET
Money Line: Tennessee Titans (-140) ; Indianapolis Colts (+118)
Total: 43; Opened: 41.5
FPI favorite: Titans by 2 (55.7% to win outright)
Line Movement Alert: Opened Colts -1
Betting Nuggets
The Titans have covered nine straight games in October. They are 11-2 ATS in October since 2020, 9-1 ATS since 2021 and 5-0 ATS since last season.
The Colts are 1-6 ATS as favorites since the start of last season. They are 1-8 ATS in their last nine games as favorites.
The Colts are 6-14 ATS in division games since 2020.
New York Giants @ Miami Dolphins -12.5
Hard Rock Stadium, Miami Gardens, Florida
Sunday 1:00 PM ET
Money Line: New York Giants (+550) ; Miami Dolphins (-800)
Total: 47.5; Opened: 47.5
FPI favorite: Dolphins by 15.5 (87% to win outright)
Line Movement Alert: Opened Dolphins -10
Betting Nuggets
Daniel Jones is 18-9 ATS on the road and 17-6 ATS as a road underdog.
Tua Tagovailoa is 8-3 ATS as a home favorite.
The Giants are 5-0 ATS in non-conference games under Brian Daboll.
The Dolphins are 1-8-1 ATS in October since 2021.
New Orleans Saints @ New England Patriots -1.5
Gillette Stadium, Foxborough, Massachusetts
Sunday 1:00 PM ET
Money Line: New Orleans Saints (+100) ; New England Patriots (-120)
Total: 39; Opened: 38.5
FPI favorite: Patriots by 1.3 (53.9% to win outright)
Betting Nuggets
All four Saints games have gone under the total this season.
Mac Jones is 12-7-1 ATS as a favorite including 5-1 ATS in his past six.
Over the last 10 seasons, the Saints are 26-10 ATS in October, while the Patriots are 26-14 ATS. The two best records in the NFL in that span.
Baltimore Ravens -4.5 @ Pittsburgh Steelers
Acrisure Stadium, Pittsburgh
Sunday 1:00 PM ET
Money Line: Baltimore Ravens (-220) ; Pittsburgh Steelers (+180)
Total: 38; Opened: 38
FPI favorite: Ravens by 8 (71.9% to win outright)
Line Movement Alert: Opened Ravens -2
Betting Nuggets
Lamar Jackson is 20-9-2 ATS in his career on the road.
The Steelers have covered four straight games after a loss.
The Ravens are 9-17 ATS as favorites over the past three seasons.
Philadelphia Eagles -4 @ Los Angeles Rams
SoFi Stadium, Inglewood, California
Sunday 4:05 PM ET
Money Line: Philadelphia Eagles (-210) ; Los Angeles Rams (+175)
Total: 50.5; Opened: 46.5
FPI favorite: Eagles by 1.9 (55.6% to win outright)
Betting Nuggets
The Eagles are 12-2-2 ATS in the last 16 meetings.
Overs are 10-4 in Jalen Hurts' last 14 starts.
This is the 25th consecutive start regular-season Jalen Hurts is favored in. Hurts is 23-2 outright and 13-10-2 ATS in his career as a favorite (22-2, 12-10-2 ATS during streak).
Matthew Stafford is 11-20-1 ATS as a home underdog in his career (1-1-1 ATS with Rams).
Cincinnati Bengals -3 @ Arizona Cardinals
State Farm Stadium, Glendale, Arizona
Sunday 4:05 PM ET
Money Line: Cincinnati Bengals (-170) ; Arizona Cardinals (+143)
Total: 45; Opened: 42.5
FPI favorite: Bengals by 5.2 (64.9% to win outright)
Betting Nuggets
The Bengals are 14-7-1 ATS after a loss since drafting Joe Burrow in 2020 (Burrow is 12-5-1 ATS after a loss).
The Cardinals are 16-8 ATS as underdogs over the past three seasons.
Joe Burrow is 27-18-1 ATS in his career, but he is 0-3-1 ATS this season.
New York Jets @ Denver Broncos -2.5
Empower Field at Mile High, Denver
Sunday 4:25 PM ET
Money Line: New York Jets (+118) ; Denver Broncos (-140)
Total: 43.5; Opened: 40
FPI favorite: Jets by 1.6 (54.7% to win outright)
Betting Nuggets
The Broncos have covered 12 of the last 17 games against the Jets.
Broncos games have gone over the total in three straight games and eight of the last nine games dating back to last season.
The Jets have gone under the total in 12 of their past 16 games and seven of their past nine games.
The Jets are 1-4 ATS in their past five games as a road underdog after starting last season 3-0 outright as a road underdog.
Kansas City Chiefs -3.5 @ Minnesota Vikings
U.S. Bank Stadium, Minneapolis
Sunday 4:25 PM ET
Money Line: Kansas City Chiefs (-190) ; Minnesota Vikings (+158)
Total: 52.5; Opened: 51.5
FPI favorite: Chiefs by 6.5 (68.1% to win outright)
Betting Nuggets
The Vikings are 1-7-1 ATS in their last nine games as an underdog.
The Chiefs are 2-5 ATS in their last seven road games.
Dallas Cowboys @ San Francisco 49ers -3.5
Levi's Stadium, Santa Clara, California
Sunday 8:20 PM ET
Money Line: Dallas Cowboys (+150) ; San Francisco 49ers (-178)
Total: 45; Opened: 45
FPI favorite: 49ers by 1.8 (55.2% to win outright)
Betting Nuggets
Brock Purdy is 9-0 outright and 7-1-1 ATS in his career as a starter.
The Cowboys have won and covered each of the last three meetings.
Eight of the last 10 meetings between the 49ers and Cowboys have gone over the total.
Dak Prescott is 15-10-1 ATS in his career as an underdog.
Green Bay Packers @ Las Vegas Raiders -2
Allegiant Stadium, Las Vegas
Monday 8:15 PM ET
Money Line: Green Bay Packers (+110) ; Las Vegas Raiders (-130)
Total: 44.5; Opened: NL
FPI favorite: Packers by 1.9 (55.5% to win outright)
Betting Nuggets
The Raiders are 0-3 ATS in their last three games. Josh McDaniels is 16-27 ATS in his last 43 games as a head coach (started 6-0 ATS).
The Packers have covered each of the last five meetings.
The Raiders are 4-0 ATS with extra rest under Josh McDaniels.